Health care is transitioning from genetics to genomics, in which single-gene testing for diagnosis is being replaced by multi-gene panels, genome-wide sequencing, and other multi-genic tests for disease diagnosis, prediction, prognosis, and treatment. This health care transition is spurring a new set of increased or novel liability risks for health care providers and test laboratories. This article describes this transition in both medical care and liability, and addresses 11 areas of potential increased or novel liability risk, offering recommendations to both (...) health care and legal actors to address and manage those liability risks. (shrink)

Genomic research results and incidental findings with health implications for a research participant are of potential interest not only to the participant, but also to the participant's family. Yet investigators lack guidance on return of results to relatives, including after the participant's death. In this paper, a national working group offers consensus analysis and recommendations, including an ethical framework to guide investigators in managing this challenging issue, before and after the participant's death.

No consensus yet exists on how to handle incidental fnd-ings in human subjects research. Yet empirical studies document IFs in a wide range of research studies, where IFs are fndings beyond the aims of the study that are of potential health or reproductive importance to the individual research participant. This paper reports recommendations of a two-year project group funded by NIH to study how to manage IFs in genetic and genomic research, as well as imaging research. We conclude that researchers (...) have an obligation to address the possibility of discovering IFs in their protocol and communications with the IRB, and in their consent forms and communications with research participants. Researchers should establish a pathway for handling IFs and communicate that to the IRB and research participants. We recommend a pathway and categorize IFs into those that must be disclosed to research participants, those that may be disclosed, and those that should not be disclosed. (shrink)

The negative emotions generated following stressful life events can increase one’s risk of depressive symptoms and promote higher levels of perceived stress. The process model of emotion regulation can help distinguish between adaptive and maladaptive emotion regulation strategies to determine who may be at the greatest risk of worse psychological health across the lifespan. Heart rate variability may affect these relationships as it indexes aspects of self-regulation, including emotion and behavioral regulation, that enable an individual to dynamically adapt to the (...) changing demands of both internal and external environments. In this study, we expected individual differences in resting vagally mediated HRV to moderate the influence of emotion regulatory strategies among our sample of 267 adults. We found support for the hypothesis that higher vagally mediated HRV buffers against the typical adverse effects of expressive suppression when evaluating depressive symptoms and found weak support when considering perceived stress. There was no evidence for an interaction between cognitive reappraisal and vagally mediated HRV but there was a significant, negative association between cognitive reappraisal and depressive symptoms and perceived stress. Future work may determine if intervening on either emotion regulation strategies or HRV may change these within-persons over time. (shrink)

Le rôle de David Hume dans la philosophie moderne, par A. L. Leroy.--The enlightenment of David Hume, by E. C. Mossner.--Hume and Jurieu: possible Calvinist origins of Hume's theory of belief, by R. H. Popkin.--Hume: philosopher or psychologist? A problem of exegesis, by T. E. Jessop.--L'astrazione nella filosofia di Hume, di M. Dal Pra.--Infinite divisibility in Hume's "Treatise," by A. Flew.--Note a "La rgola del gusto," di E. Migliorini.--Kant, Hamann-Jacobi and Schelling on Hume, by P. Merlan.--Bibliografia humiana dal 1937 (...) al 1966, di E. Ronchetti. (shrink)

Returning genomic research results to family members raises complex questions. Genomic research on life-limiting conditions such as cancer, and research involving storage and reanalysis of data and specimens long into the future, makes these questions pressing. This author group, funded by an NIH grant, published consensus recommendations presenting a framework. This follow-up paper offers concrete guidance and tools for implementation. The group collected and analyzed relevant documents and guidance, including tools from the Clinical Sequencing Exploratory Research Consortium. The authors then (...) negotiated a consensus toolkit of processes and documents. That toolkit offers sample consent and notification documents plus decision flow-charts to address return of results to family of living and deceased participants, in adult and pediatric research. Core concerns are eliciting participant preferences on sharing results with family and on choice of a representative to make decisions about sharing after participant death. (shrink)

The selections contained in these volumes from the papers and letters of Leibniz are intended to serve the student in two ways: first, by providing a more adequate and balanced conception of the full range and penetration of Leibniz's creative intellectual powers; second, by inviting a fresher approach to his intellectual growth and a clearer perception of the internal strains in his thinking, through a chronological arrangement. Much confusion has arisen in the past through a neglect of the develop ment (...) of Leibniz's ideas, and Couturat's impressive plea, in his edition of the Opuscu/es et fragments (p. xii), for such an arrangement is valid even for incomplete editions. The beginning student will do well, however, to read the maturer writings of Parts II, III, and IV first, leaving Part I, from a period too largely neglected by Leibniz criticism, for a later study of the still obscure sources and motives of his thought. The Introduction aims primarily to provide cultural orientation and an exposition of the structure and the underlying assumptions of the philosophical system rather than a critical evaluation. I hope that together with the notes and the Index, it will provide those aids to the understanding which the originality of Leibniz's scientific, ethical, and metaphysical efforts deserve. (shrink)

Pickering & Garrod's (P&G's) call to study language processing in dialogue context is an appealing one. Their interactive alignment model is ambitious, aiming to explain the converging behavior of dialogue partners via both intra- and interpersonal priming. However, they ignore the flexible, partner-specific processing demonstrated by some recent dialogue studies. We discuss implications of these data.

In lieu of an abstract, here is a brief excerpt of the content:136 HISTORY OF PHILOSOPHY man felt two needs :"the theoretical need for guaranteeing a priori the subsistence of an ethical sphere against the Enlightenment's emphasis on happiness, and the political and practical need for guaranteeing individual freedom against an enlightened absolutism" (p. 71). Owing to this double need, Kant seems to be against himself and consequently the most critical and dialectical interpretation of Kant's thought is opposed to the (...) formalistic absolutism used by the Kantian jurists, who reject the most vital and profound critical philosophy for a metaphysical framework which confuses everything as though all were homogeneous. In fact, what appears more valid in Kant's philosophy is the continuous tension between formalism and dialectics, a tension which, even though it is never definitively overcome in a dialectical sense by Kant himself, nevertheless reveals the need for a legal dialectic rather than a formalism. It shows "the destiny of legal right to cease being a coercive apparatus, and of being transformed into rules for human society taken from civil society" (p. 390). Of course, this dialectical perspective suggests new horizons and also new problems and a wide plan of work. However, I agree with the author that the uncertainties which will inevitably emerge in this work must be met urgently and radically. For we know that "on the other scale-pan there are in fact the raw metaphysics of legal positivism, the conservatism of the jurists, and at best the formalistic, paralyzing ascetics" (p. 390). The merit of Negri's book seems to me to lie above all in the lively problematical tension with which he examines the Kantian thought. Following in the paths of G. Gurwitch, Metzger and Goldmann, as well as of Luk~s' History and Class Consciousness, he appreciates and understands the interpenetration of ethical motivations with the social and cultural environment. This historical and philosophical awareness of problems is particularly lively in the pages where the author notices the begging of principle in Kantian thought; a begging of principle consisting in the fact that "the definition of limit presupposes a limit to the principle itself, but the examination of this presupposition is neglected" (p. 77 ft.). Because of this critical and historical tension, Negri's book can be of great interest to the jurist, the philosopher and the historian. And if this ensues, it is because the conception of legal right which the author seeks to assert throughout his theoretical tension is deep-rooted humanly, dialectically, concretely. It is most needed by those who really want to make of law and right not a formal science but a human science. ANTONELLA GUARALDI Bari, Italy The Narrow Pass: Kierkegaard's Concept of Man. By George Price. (New York, Toronto, London: McGraw-Hill Book Co., 1963. Pp. 5-218.) Selon hombre de ses commentateurs, Kierkegaard seralt un ehrdtien passionnd; pour d'autres, il serait une sorte d'incroyant; pour George Price, nous devrions lui accorder une unitd complexe, unitd de production, qui s'exprime directement par la suite de ses oeuvres, unitd d'intention, une vue religicuse qui repose sur une certaine conception de l'homme, un th~me fondamental aussi qui est au centre des diverses discussions sur le pdchd, la foi, la raison, la morale, la subjectivitd et le "paradoxe", tous ces probl~mes qui paraissent se poser et se reposer sans cesse pour Kierkegaard, toujours de mani~re assez nouvelle. L'homme est i~la fois une synth~se de son corps et de son moi, des causes qui ont d'abord faeonnd son ~tre, et de qu'il y a en lui d'original et qui ne sera jamais rdpdtd, ce que son esprit a fait par un effort crdateur. Et d'abord une premiere remarque pour simplifier les vues de Kierkegaard. II n'y a pas ici de substances conjointes, il n'y a que des dvdnements corporels et spirituels. L'influence de Fichte apparait par l'importance accordde au devenir, un devenir qui se poursuit selon un module et qui reste fragile, si la volontd de se rdaliser ne se maintient pas. L'homme dolt se passionner pour son existence, it dolt devenir lui-m~me. La chute de l... (shrink)

In this chapter the explanatory value of four conceptions of human dignity to account for two seemingly contradictory intuitions is tested. One is that many people think poverty violates the humanity of poor people. The other intuition is that poor people often act with remarkable dignity despite their trying circumstances. First Immanuel Kant’s influential view on human dignity that claims it is grounded in humans’ capability to make moral judgments is examined. Next, Martha Nussbaum’s theory of the capability approach is (...) tested, which is hugely influential across many academic disciplines and in the world of economic development. Thereafter, two related, though distinctly different African theories of human dignity, as offered by Thaddeus Metz and Polycarp Ikuenobe are assessed. Both base their theories on the core capacity of humans to engage in harmonious relationships within communities. Last, it is investigated the theory that Avishai Margalit provides of honour and humiliation as concepts that illuminate the value and risks for humans’ possession of dignity. His theory is linked to aspects of the recognition theory of Axel Honneth. In the end, it is concluded that these theories either cannot fully, or adequately, explain the complex relationship between poverty and human dignity. (shrink)

In this article I respond to the thoughtful criticisms of my book articulated by Gillian Brock, Thaddeus Metz, and Darrel Moellendorf. Their critical questioning offers me an opportunity to reformulate aspects of the book so that I more accurately say exactly what I had in mind when writing the book. The first section contains a reworking of my definition of poverty to eliminate any ambiguity and demonstrate what kind of comparative judgements the definition allows us to make. The second section (...) looks anew at the multiple moral sources for our obligation to eradicate poverty. In the third section I focus on issues that could hinder attempts at eradicating poverty. One is the lack of accessible knowledge that might be too demanding to acquire. The other is the possibility that all attempts to eradicate poverty might have to be put on hold until oppressive capitalist development has prepared the circumstances for a more socialist distribution of resources. I argue that neither of these concerns should hinder the eradication of poverty. (shrink)

Cette plaquette, de facture élégante, est due à un chercheur spécialisé dans l'histoire de la population de Metz sous la Révolution et l'Empire. Louise Louise de Poutet fait partie de ces femmes qui ont divorcé pendant la Révolution, contracté un nouveau mariage, puis réépousé leur premier mari. L'attention du chercheur a été retenue par une pièce d'archive : un mémoire du second époux. Loin d'apparaître comme un partenaire fictif, c'est un amoureux payé de retour qui proteste contre l..

Cette plaquette, de facture élégante, est due à un chercheur spécialisé dans l'histoire de la population de Metz sous la Révolution et l'Empire. Louise Louise de Poutet fait partie de ces femmes qui ont divorcé pendant la Révolution, contracté un nouveau mariage, puis réépousé leur premier mari. L'attention du chercheur a été retenue par une pièce d'archive : un mémoire du second époux. Loin d'apparaître comme un partenaire fictif, c'est un amoureux payé de retour qui proteste contre l...

Dans le cadre du groupe de Recherches en littérature et spiritualité, fondé à l’Université de Metz, le volume publié par N. Brucker fait place à un large éventail de genres et d’œuvres littéraires, de saint Paul à nos jours. Plus de vingt communications au total, regroupées en six sections, dont les titres (« Spiritualité, éthique et société », « Homme nouveau, nouvelle écriture ? », par exemple) marquent, il faut le reconnaître, ce que risque d’avoir d’artificiel une telle tentative de (...) class.. (shrink)

In _A Relational Moral Theory: African ethics in and beyond the continent_ ( 2022 ), Thaddeus Metz proposes an African moral theory according to which we ought to respect and honour the capacity of individuals to be party to harmonious relationship. He aims to present a moral theory that should ‘be weighed up against at least contemporary Western moral theories’ (p. 2). As Metz intends his theory to be a serious contender with other moral theories, I assess how his moral (...) theory can be applied and contribute to contemporary moral discussions _‘beyond the continent’_, as the subtitle of the book puts it. In particular, as Metz’s relational moral theory is grounded on the value of harmony, an important question is how well his theory handles _disharmony_ especially if his theory is to have application in our non-ideal world in which disharmony is rife. And here, I hold up Metz’s account to one area of disharmony, disruptive emotions and affective injustice. By first establishing how disruptive emotions and affective injustice pose a challenge to similar relational moral theories grounded in harmony, I argue that Metz’s theory has distinct advantages in the way in which it can indeed engage with such phenomena. I close the paper by considering the objection that Metz’s account is limited in making sense of a common form of disruptive emotion in response to structural injustices where affective injustice can arise, but ultimately conclude that such a limitation is superficial. (shrink)

L'ouvrage est le fruit d'une recherche-action menée par deux chercheurs que leurs responsabilités ecclésiales conduisent à rencontrer et accompagner, non seulement des jeunes de 13 à 18 ans, mais également des parents, des enseignants et enseignantes, des éducateurs et éducatrices. Après avoir assuré durant plus de quinze ans la responsabilité d'aumônerie de lycées et collèges dans le diocèse de Metz, Ch. Aulenbacher est maître de conférences en théologie pratique dans notre Faculté. Chercheu..

Scientific realists have suggested that changes in our scientific communities over the course of their history have rendered those communities progressively less vulnerable to the problem of unconcieved alternatives over time. I argue in response not only that the most fundamental historical transformations of the scientific enterprise have generated steadily mounting obstacles to revolutionary, transformative, or unorthodox scientific theorizing, but also that we have substantial independent evidence that the institutional apparatus of contemporary scientific inquiry fosters an exceedingly and increasingly theoretically (...) conservative form of that inquiry. I conclude that contemporary scientific communities are actually more vulnerable to the problem of unconceived alternatives than their historical predecessors, and I briefly suggest how we might seek to pursue scientific inquiry in a less theoretically conservative way. (shrink)

Inleidend overzicht van de wijsgerige ethiek.

Together again for the first time, Marx and Durkheim join forces in the pages of Disintegration: Bad Love, Collective Suicide, and the Idols of Imperial Twilight for a dialectical exploration of the moral economy of neoliberalism, animated, as it is not only by the capitalist chase for surplus value, but also by an immortal vortex of sacred powers. Classical sociology and psychoanalysis are reconstituted within Hegelian social ontology and dialectical method that differentiates between the ephemeral and free and the eternal (...) and fixed aspects of modern life. (shrink)